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江苏快3 > 产品展示 > 生化试剂 > 其它常用试剂 >3-异丁基-1-甲基黄嘌呤,Santa IBMX ,CAS 28822-58-4
  • 3-异丁基-1-甲基黄嘌呤,Santa IBMX ,CAS 28822-58-4
  • 3-异丁基-1-甲基黄嘌呤,Santa IBMX ,CAS 28822-58-4
    慧颖生物强势代购Santa CRUZ全线产品,货期短,价格优惠,!3-异丁基-1-甲基黄嘌呤,Santa IBMX ,CAS 28822-58-4,有200MG和1G包装,如您有需要,请您致电我司。

    3-异丁基-1-甲基黄嘌呤,Santa IBMX ,CAS 28822-58-4

    产品名称:3-异丁基-1-甲基黄嘌呤

    英文名称:IBMX

    同义词:3-Isobutyl-1-methylanxthine; Methylisobutylxanthine; MIX

    品牌:Santa CRUZ

    货号:sc-201188

    CAS号:28822-58-4

    纯度:≥99%

    分子量大小:222.24

    分子式:C10H14N4O2

    规格:200 mg和1 g

    货期:2周

    特惠价格:致电咨询

    英文描述:

    IBMX is one of the most potent and nonspecific inhibitors of cyclic nucleotide PDE (phosphodiesterases) with documented IC50 values for PDE1, 2, 3, 4, and 5 equaling 19, 50, 18, 13 and 32。 The compound is documented to raise intracellular cyclic AMP levels。 In rat sensory neurons the addition of IBMX caused the release of Ca2+ from caffeine ryanodine sensitive internal stores increasing the internal Ca2+ levels and inducing a biphasic membrane current response。 Through PDE inhibition IBMX has also inhibited TNFα。 IBMX in breast cancer cells has also induced p21 and p27 through a PKA independent pathway。 Although a nonspecific PDE inhibitor IBMX does not show inhibition of PDE8B。 In neuroendocrine epithelial cells IBMX has been observed to inhibit α-adrenoceptor-mediated 5-HT release at IC50 = 1。3μM。

    技术信息:

    物理状态:Solid

    溶解度:Soluble in ethanol (10 mg/ml), DMSO(with gentle warming) (1 M), methanol(warm) (50 mg/ml), 2-propanol, dichloromethane, ether, ethyl acetate, and DMF (~5 mg/ml). Insoluble in water.

    存储:Store at room temperature

    熔点:200-201 °C (lit.)

    沸点:445.6 °C at 760 mmHg (Predicted)

    浓度:1。3 g/cm3 (Predicted)

    折射率:n20D 1.57 (Predicted)

    IC50: suppresses α-adrenoceptor-mediated 5-HT release: IC50 = 1。3 μM (neuroendocrine epithelial cells); PDE4: IC50 = 13 μM; PDE3: IC50 = 18 μM; PDE1: IC50 = 19 μM; PDE5 : IC50 = 32 μM; PDE2: IC50 = 50 μM; Phosphodiesterase 1B: IC50 = 100 nM (rat); Sodium channel protein type II alpha subunit: IC50 = 1800 nM (human)

    Ki数据:Adenosine A2b receptor: Ki= 50 nM (rat); Adenosine A2a receptor: Ki= 800 nM (rat); Adenosine A1 receptor: Ki= 2000 nM (rat)

    pK值:pKa: 8。61 (Predicted), pKb: 1。49 (Predicted)


    注意:本产品仅供科研使用。不可用于诊断或治疗。

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